An amidoxime reductase system in adipocyte mitochondria containing cytochrome b5 type B (CYB5B) and molybdenum cofactor sulfurase C-terminal containing 2 (MOSC2) of importance for lipid synthesis
نویسندگان
چکیده
Background: High amidoxime reductase activity is found in liver and fat tissue, although its composition in cells is unknown. Results: Amidoxime reductase is upregulated during adipogenesis and requires MOSC2 and CYB5B. Conclusion: MOSC2 and CYB5B are essential components of the mitochondrial amidoxime reductase and MOSC2 is important for lipogenesis. Significance: We suggest a role of MOSC2 in adipogenesis and fatty acid synthesis and as a potential novel drug target.
منابع مشابه
Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.
Reduction of hydroxylamines and amidoximes is important for drug activation and detoxification of aromatic and heterocyclic amines. Such a reductase system was previously found to be of high activity in adipose tissue and liver, and furthermore, in vitro studies using recombinant truncated and purified enzymes suggested the participation of cytochrome b(5) reductase (CYB5R), cytochrome b(5) (CY...
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